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p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes.

Abstract:

p38 mitogen-activated protein kinase (MAPK) is activated by inflammatory stimuli such as bacterial lipopolysaccharide (LPS), interleukin-1, and tumor necrosis factor. We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts. Here we explore the role of p38 MAPK in the response of human monocytes to LPS. 0.1 microM SB 203580 significantly inhibited...

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Publisher copy:
10.1074/jbc.274.1.264

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Journal:
The Journal of biological chemistry
Volume:
274
Issue:
1
Pages:
264-269
Publication date:
1999-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:bbcd6595-3ce8-4f87-8de8-734e158bdb73
Source identifiers:
430184
Local pid:
pubs:430184

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