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What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus?

Abstract:

The role of cytotoxic T lymphocytes (CTL) in human immunodeficiency virus (HIV) infection remains elusive. Since the discovery 10 years ago of high levels of specific CTL in this disease, some have argued that they play an important role in virus control, others that they drive disease progression through destruction of T helper cells, and others still that they play no obvious role at all. By contrast, the central role of CTL in murine lymphocytic choriomeningitis virus (LCMV) infection has ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Zinkernagel, RM More by this author
Journal:
Immunological reviews
Volume:
159
Issue:
1
Pages:
5-16
Publication date:
1997-10-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:bbca8d80-c6ba-4514-8b77-f0e27f015605
Source identifiers:
31083
Local pid:
pubs:31083

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