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Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.

Abstract:

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resista...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2624

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Almagro-Garcia, J More by this author
Macinnis, B More by this author
Campino, S More by this author
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Journal:
Nature genetics
Volume:
45
Issue:
6
Pages:
648-655
Publication date:
2013-06-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:bbc44ea9-f76a-4a09-b3d0-8e0125b88aef
Source identifiers:
401557
Local pid:
pubs:401557

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