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CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation.

Abstract:

UNLABELLED: Hepatitis C virus (HCV) causes chronic infection accompanied by a high risk of liver failure and hepatocellular carcinoma. CD8+ T cell responses are important in the control of viremia. However, the T cell response in chronic infection is weak both in absolute numbers and in the range of epitopes targeted. In order to explore the biology of this response further, we analyzed expression of a panel of natural killer cell markers in HCV compared with other virus-specific T cell popu...

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Publication status:
Published

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Publisher copy:
10.1002/hep.22040

Authors


Northfield, JW More by this author
Kasprowicz, V More by this author
Kersting, N More by this author
Bengsch, B More by this author
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Journal:
Hepatology (Baltimore, Md.)
Volume:
47
Issue:
2
Pages:
396-406
Publication date:
2008-02-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:bbbcec20-6478-4ea2-8ec5-c9502df52008
Source identifiers:
29265
Local pid:
pubs:29265

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