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A mathematical model for collagen fibre formation during foetal and adult dermal wound healing

Abstract:

Adult dermal wounds, in contrast to foetal wounds, heal with the formation of scar tissue. A crucial factor in determining the nature of the healed tissue is the ratio of collagen 1 to collagen 3, which regulates the diameter of collagen fibres. We develop a mathematical model which focuses on the stimulus for collagen synthesis due to the secretion of the different isoforms of the regulatory chemical transforming growth factor $\beta $. Numerical simulations of the model lead to a value of t...

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P. D. Dale More by this author
J. A. Sherratt More by this author
P. K. Maini More by this author
Publication date:
1996
URN:
uuid:bbbbfdda-245d-48cc-8e4a-7d88f64314b9
Local pid:
oai:eprints.maths.ox.ac.uk:461

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