Journal article

### A mathematical model for collagen fibre formation during foetal and adult dermal wound healing

Abstract:

Adult dermal wounds, in contrast to foetal wounds, heal with the formation of scar tissue. A crucial factor in determining the nature of the healed tissue is the ratio of collagen 1 to collagen 3, which regulates the diameter of collagen fibres. We develop a mathematical model which focuses on the stimulus for collagen synthesis due to the secretion of the different isoforms of the regulatory chemical transforming growth factor $\beta$. Numerical simulations of the model lead to a value of t...

Files:
• (pdf, 1.5MB)

### Authors

Publication date:
1996-01-01
URN:
uuid:bbbbfdda-245d-48cc-8e4a-7d88f64314b9
Local pid:
oai:eprints.maths.ox.ac.uk:461

### Metrics

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP