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Journal article

Increased default-mode network centrality in cognitively impaired multiple sclerosis patients

Abstract:

Objective: To investigate how changes in functional network hierarchy determine cognitive impairment in multiple sclerosis (MS).

Methods: A cohort consisting of 332 patients with MS (age 48.1 ± 11.0 years, symptom duration 14.6 ± 8.4 years) and 96 healthy controls (HCs; age 45.9 ± 10.4 years) underwent structural MRI, fMRI, and extensive neuropsychological testing. Patients were divided into 3 groups: cognitively impaired (CI; n = 87), mildly cognitively impaired (MCI; n = 65), and...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Eijlers, AJ More by this author
Meijer, KA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Steenwijk, MD More by this author
Uitdehaag, BM More by this author
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Publisher:
American Academy of Neurology Publisher's website
Journal:
Neurology Journal website
Volume:
88
Issue:
10
Pages:
952-960
Publication date:
2017-03-07
Acceptance date:
2016-12-12
DOI:
ISSN:
0028-3878 and 1526-632X
Pubs id:
pubs:680398
URN:
uri:bbb6ed11-cf9d-4cde-91db-6d3a80fce5f7
UUID:
uuid:bbb6ed11-cf9d-4cde-91db-6d3a80fce5f7
Local pid:
pubs:680398
Language:
English
Keywords:

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