Journal article icon

Journal article

Targeting host-derived glycans on enveloped viruses for antibody-based vaccine design

Abstract:

The surface of enveloped viruses can be extensively glycosylated. Unlike the glycans coating pathogens such as bacteria and fungi, glycans on viruses are added and processed by the host-cell during biosynthesis. Glycoproteins are typically subjected to α-mannosidase processing and Golgi-mediated glycosyltransferase extension to form complex-type glycans. In envelope viruses, exceptions to this default pathway are common and lead to the presence of oligomannose-type glycan structures on the vi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Oxford college:
Corpus Christi College
Department:
Oxford, MSD, Biochemistry
Doores, KJ More by this author
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Virology Journal website
Volume:
11
Pages:
63-69
Publication date:
2015-03-06
DOI:
EISSN:
1879-6265
ISSN:
1879-6257
Pubs id:
pubs:604654
URN:
uri:bbb0682d-cb3b-410a-83e0-71d25e963de8
UUID:
uuid:bbb0682d-cb3b-410a-83e0-71d25e963de8
Local pid:
pubs:604654
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP