- Abstract:
-
AIMS: To investigate the effects of two single nucleotide polymorphisms (SNPs) in the human P2X₇ receptor gene (P2RX7)--1068G>A (A348T) and 1513A>C (E496A)--on P2X₇ receptor function, using a specific receptor antagonist (GSK1370319A) and prospective genetic stratification. METHODS: Lipopolysaccharide- and ATP-stimulated interleukin-1β production was determined in the presence or absence of GSK1370319A in blood culture from 32 prospectively genotyped subjects. RESULTS: There was approx...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2125.2012.04200.x
-
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- Journal:
- British journal of clinical pharmacology
- Volume:
- 74
- Issue:
- 2
- Pages:
- 376-380
- Publication date:
- 2012-08-05
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- URN:
-
uuid:bba6c49e-0c6b-4c67-addf-040da9a5836c
- Source identifiers:
-
245902
- Local pid:
- pubs:245902
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach.
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