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Journal article

Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach.

Abstract:

AIMS: To investigate the effects of two single nucleotide polymorphisms (SNPs) in the human P2X₇ receptor gene (P2RX7)--1068G>A (A348T) and 1513A>C (E496A)--on P2X₇ receptor function, using a specific receptor antagonist (GSK1370319A) and prospective genetic stratification. METHODS: Lipopolysaccharide- and ATP-stimulated interleukin-1β production was determined in the presence or absence of GSK1370319A in blood culture from 32 prospectively genotyped subjects. RESULTS: There was approx...

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Publication status:
Published

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Authors


McHugh, SM More by this author
Pickett, AM More by this author
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Journal:
British journal of clinical pharmacology
Volume:
74
Issue:
2
Pages:
376-380
Publication date:
2012-08-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:bba6c49e-0c6b-4c67-addf-040da9a5836c
Source identifiers:
245902
Local pid:
pubs:245902

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