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Journal article

Helicobacter pylori depletes cholesterol in gastric glands to prevent interferon gamma signaling and escape the inflammatory response

Abstract:

Background and Aims

Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of cholesterol-aglucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. We investigated how cgt affects gastric epithelial cells and the host immune response.

Methods

MKN45 gastric epithelial cells, AGS cells, and human primary gastric epithelial cells (obtained from patients ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1053/j.gastro.2017.12.008

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0001-6013-7154
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German Research Foundation More from this funder
Berlin Institute of Health More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Gastroenterology Journal website
Volume:
154
Issue:
5
Pages:
1391-1404.e9
Publication date:
2017-12-19
Acceptance date:
2017-12-14
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
Pubs id:
pubs:939817
URN:
uri:bba6b27a-58d6-484d-9ad0-31b4aba52f72
UUID:
uuid:bba6b27a-58d6-484d-9ad0-31b4aba52f72
Local pid:
pubs:939817

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