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Thesis

Interaction and immune regulations of innate lymphoid cells and plasmacytoid dendritic cells in skin inflammatory diseases

Abstract:

The skin is equipped with an immune network providing surveillance and effector function. Plasmacytoid dendritic cells (pDCs) are found to accumulate in skin wounds, yet the mechanisms of their role in skin wound healing are hitherto unstudied. Here, BDCA-2+ DCs were shown to infiltrate in vivo human wounds, showing heterogeneity based on differential expression of CD123, with a CD123int DC subset expressing CD1a at high levels. The CD1a+-bearing subsets could be derived from...

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Department:
Human Immunology Unit

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Keywords:

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