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Bacterial handling defect in macrophages of patients with defects in glucose-6-phosphate metabolism and Crohn's disease like intestinal inflammation

Abstract:

Aberrant innate bacterial handling is one of the key mechanisms underlining Crohn’s disease (CD). Recently, in several inflammatory disorders defects in immunometabolism have been described but it is not clear whether this is a primary or secondary effect. Several monogenic immunodeficiencies that affect phagocyte activity present as Mendelian disorder associated inflammatory bowel disease. One intriguing subgroup is the group of patients with Glycogen storage disease type Ib (GSD-Ib) and con...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ecco-jcc/jjx180.164

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0001-7580-2567
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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John Fell Fund More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
13th Congress of ECCO – European Crohn’s and Colitis Organisation Journal website
Volume:
12
Issue:
supplement_1
Pages:
S111
Host title:
Journal of Crohn's and Colitis
Publication date:
2018-01-16
Acceptance date:
2017-12-22
DOI:
Source identifiers:
844062
Pubs id:
pubs:844062
UUID:
uuid:bb971695-ef99-4357-a0b7-3e54ba386546
Local pid:
pubs:844062
Deposit date:
2018-09-17

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