Journal article icon

Journal article

Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency.

Abstract:

The molecular diversity of many gene products functioning in the nervous system is enhanced by alternative splicing and adenosine-to-inosine editing of pre-mRNA. Using RDL, a Drosophila melanogaster GABA-gated ion channel, we examined the functional impact of RNA editing at several sites along with alternative splicing of more than one exon. We show that alternative splicing and RNA editing have a combined influence on the potency of the neurotransmitter GABA, and the editing isoforms detecte...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Buckingham, SD More by this author
Papadaki, M More by this author
Sattelle, BM More by this author
Expand authors...
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
29
Issue:
13
Pages:
4287-4292
Publication date:
2009-04-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:bb943f19-a26b-454c-84e3-f0da73bd85d8
Source identifiers:
244253
Local pid:
pubs:244253

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP