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Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450cam.

Abstract:

Oxygenated derivatives of the monoterpene (+)-alpha-pinene are found in plant essential oils and used as fragrances and flavorings. (+)-alpha-Pinene is structurally related to (+)-camphor, the natural substrate of the heme monooxygenase cytochrome P450(cam) from Pseudomonas putida. The aim of the present work was to apply the current understanding of P450 substrate binding and catalysis to engineer P450(cam) for the selective oxidation of (+)-alpha-pinene. Consideration of the structures of (...

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Publication status:
Published

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Publisher copy:
10.1021/ja028460a

Authors


Sowden, RJ More by this author
Williams, JN More by this author
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Journal:
Journal of the American Chemical Society
Volume:
125
Issue:
3
Pages:
705-714
Publication date:
2003-01-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:bb739b10-ce7b-441a-9dca-4bbd863e715a
Source identifiers:
32296
Local pid:
pubs:32296

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