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DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

Abstract:

Background

This article on choosing the target difference for a randomised controlled trial (RCT) and undertaking and reporting the sample size calculation has been dual published in the BMJ and BMC Trials journals. A key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target difference between the treatments for the primary outcome and then calculate the required sample size. The sample si...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13063-018-2884-0

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
Botnar Research Centre
Oxford college:
St Hughs College; St Hughs College
ORCID:
0000-0002-4156-6989
Julious, SA More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; CSM
Hampson, LV More by this author
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Medical Research Council More from this funder
National Institute for Health Research More from this funder
Chief Scientist Office of the Scottish Government More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
19
Pages:
606
Publication date:
2018-11-05
Acceptance date:
2018-08-29
DOI:
EISSN:
1745-6215
ISSN:
1745-6215
Pubs id:
pubs:911768
URN:
uri:bb7008fa-d286-4a63-a8e7-edcfaaf7be2b
UUID:
uuid:bb7008fa-d286-4a63-a8e7-edcfaaf7be2b
Local pid:
pubs:911768

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