GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron and preventing pressure natriuresis.
Although sodium retention and volume expansion occur during GH administration, blood pressure is decreased or unchanged. The aim was to study the effect of short- and long-term GH replacement in adults on sodium balance, renal hemodynamics, and blood pressure. Ten adults with severe GH deficiency were included into a 7-d, randomized, placebo-controlled, cross-over trial followed by 12 months of open GH replacement. All measurements were performed under metabolic ward conditions. Extracellular...Expand abstract
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- The Journal of clinical endocrinology and metabolism
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