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GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron and preventing pressure natriuresis.

Abstract:

Although sodium retention and volume expansion occur during GH administration, blood pressure is decreased or unchanged. The aim was to study the effect of short- and long-term GH replacement in adults on sodium balance, renal hemodynamics, and blood pressure. Ten adults with severe GH deficiency were included into a 7-d, randomized, placebo-controlled, cross-over trial followed by 12 months of open GH replacement. All measurements were performed under metabolic ward conditions. Extracellular...

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Publisher copy:
10.1210/jc.87.4.1743

Authors


Johannsson, G More by this author
Sverrisdóttir, YB More by this author
Ellegård, L More by this author
Lundberg, PA More by this author
Herlitz, H More by this author
Journal:
The Journal of clinical endocrinology and metabolism
Volume:
87
Issue:
4
Pages:
1743-1749
Publication date:
2002-04-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:bb6d26fb-ba27-4414-8621-54d76635f019
Source identifiers:
260650
Local pid:
pubs:260650

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