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Rapid effector function of varicella-zoster virus glycoprotein I-specific CD4+ T cells many decades after primary infection.

Abstract:

Glycoprotein I (gI) of varicella-zoster virus (VZV) contributes to viral virulence and is therefore a potentially important target for T cell control of viral replication. Persisting effector function of gI-specific T cells after primary infection has not been previously examined. We have shown that, many decades after infection, relatively high frequencies gI-specific interferon- gamma responses are detectable ex vivo and are dominated by CD4(+) T cells. We characterized the optimal peptide ...

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Publication status:
Published

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Publisher copy:
10.1086/511274

Authors


Malavige, GN More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-CTU
Journal:
The Journal of infectious diseases
Volume:
195
Issue:
5
Pages:
660-664
Publication date:
2007-03-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:bb629c30-9f05-49ad-b549-619eddecb047
Source identifiers:
21591
Local pid:
pubs:21591

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