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Journal article

The impact of administration of conjugate vaccines containing cross reacting material on Haemophilus influenzae type b antibody responses in infants: A systematic review and meta-analysis of randomised controlled trials

Abstract:

Protein-polysaccharide conjugate vaccines such as Haemophilus influenzae type b (Hib), meningococcal, and pneumococcal vaccine, induce immunological memory and longer lasting protection than plain polysaccharide vaccines. The most common proteins used as carriers are tetanus toxoid (TT) and cross reacting material-197 (CRM), a mutant form of diphtheria toxoid. CRM conjugate vaccines have been reported to suppress antibody responses to co-administered Hib-TT vaccine.We conducted a systematic r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vaccine.2016.06.038

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More from this funder
Funding agency for:
Voysey, M
Grant:
DRF-2015-08-048
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
34
Issue:
34
Pages:
3986-3992
Publication date:
2016-07-25
Acceptance date:
2016-06-10
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Source identifiers:
631096
Language:
English
Keywords:
Pubs id:
pubs:631096
UUID:
uuid:bb5ea805-fd42-4201-b263-68f385183961
Local pid:
pubs:631096
Deposit date:
2016-07-19

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