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Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements.

Abstract:

The oxygen-regulated control system responsible for the induction of erythropoietin (Epo) by hypoxia is present in most (if not all) cells and operates on other genes, including those involved in energy metabolism. To understand the organization of cis-acting sequences that are responsible for oxygen-regulated gene expression, we have studied the 5' flanking region of the mouse gene encoding the hypoxically inducible enzyme lactate dehydrogenase A (LDH). Deletional and mutational analysis of ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.270.36.21021

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Journal of biological chemistry
Volume:
270
Issue:
36
Pages:
21021-21027
Publication date:
1995-09-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
24757

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