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Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements.

Abstract:

The oxygen-regulated control system responsible for the induction of erythropoietin (Epo) by hypoxia is present in most (if not all) cells and operates on other genes, including those involved in energy metabolism. To understand the organization of cis-acting sequences that are responsible for oxygen-regulated gene expression, we have studied the 5' flanking region of the mouse gene encoding the hypoxically inducible enzyme lactate dehydrogenase A (LDH). Deletional and mutational analysis of ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.270.36.21021

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
270
Issue:
36
Pages:
21021-21027
Publication date:
1995-09-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:bb45bc09-a285-4aae-93d8-54fed6e85ad3
Source identifiers:
24757
Local pid:
pubs:24757

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