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The complex of Arl2-GTP and PDE delta: from structure to function.

Abstract:

Arf-like (Arl) proteins are close relatives of the Arf regulators of vesicular transport, but their function is unknown. Here, we present the crystal structure of full-length Arl2-GTP in complex with its effector PDE delta solved in two crystal forms (Protein Data Bank codes 1KSG, 1KSH and 1KSJ). Arl2 shows a dramatic conformational change from the GDP-bound form, which suggests that it is reversibly membrane associated. PDE delta is structurally closely related to RhoGDI and contains a deep ...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/21.9.2095

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The EMBO journal
Volume:
21
Issue:
9
Pages:
2095-2106
Publication date:
2002-05-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:bb3fbb71-291a-4311-9e7a-36bc6ae02086
Source identifiers:
27564
Local pid:
pubs:27564

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