- Abstract:
-
Arf-like (Arl) proteins are close relatives of the Arf regulators of vesicular transport, but their function is unknown. Here, we present the crystal structure of full-length Arl2-GTP in complex with its effector PDE delta solved in two crystal forms (Protein Data Bank codes 1KSG, 1KSH and 1KSJ). Arl2 shows a dramatic conformational change from the GDP-bound form, which suggests that it is reversibly membrane associated. PDE delta is structurally closely related to RhoGDI and contains a deep ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/emboj/21.9.2095
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- Journal:
- The EMBO journal
- Volume:
- 21
- Issue:
- 9
- Pages:
- 2095-2106
- Publication date:
- 2002-05-05
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- URN:
-
uuid:bb3fbb71-291a-4311-9e7a-36bc6ae02086
- Source identifiers:
-
27564
- Local pid:
- pubs:27564
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
The complex of Arl2-GTP and PDE delta: from structure to function.
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