Journal article
The complex of Arl2-GTP and PDE delta: from structure to function.
- Abstract:
-
Arf-like (Arl) proteins are close relatives of the Arf regulators of vesicular transport, but their function is unknown. Here, we present the crystal structure of full-length Arl2-GTP in complex with its effector PDE delta solved in two crystal forms (Protein Data Bank codes 1KSG, 1KSH and 1KSJ). Arl2 shows a dramatic conformational change from the GDP-bound form, which suggests that it is reversibly membrane associated. PDE delta is structurally closely related to RhoGDI and contains a deep ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/emboj/21.9.2095
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Authors
Bibliographic Details
- Journal:
- EMBO journal
- Volume:
- 21
- Issue:
- 9
- Pages:
- 2095-2106
- Publication date:
- 2002-05-01
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- Source identifiers:
-
27564
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:27564
- UUID:
-
uuid:bb3fbb71-291a-4311-9e7a-36bc6ae02086
- Local pid:
- pubs:27564
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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