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Persistent global inflammation caused by the loss of SIRT1 protects against experimental osteoarthritis

Abstract:

Inflammatory pathways have been attributed to play a central role in the pathogenesis of osteoarthritis (OA). However, most previous studies using knockout (KO) mice to inactivate inflammatory genes have showed no significant protection in experimental OA. In addition, biologic treatments targeting cytokines in OA have showed poor efficacy in clinical studies. This raises the question whether persistent inflammation has a central role in driving disease. The histone deacetylase Sirtuin 1 (SIR...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.joca.2017.02.084

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
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Publisher:
Elsevier Publisher's website
Publication date:
2017-04-18
Acceptance date:
2017-01-09
DOI:
Pubs id:
pubs:724456
URN:
uri:bb3d7ab9-766c-4a0f-9d06-9238704cea29
UUID:
uuid:bb3d7ab9-766c-4a0f-9d06-9238704cea29
Local pid:
pubs:724456

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