- Abstract:
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Inflammatory pathways have been attributed to play a central role in the pathogenesis of osteoarthritis (OA). However, most previous studies using knockout (KO) mice to inactivate inflammatory genes have showed no significant protection in experimental OA. In addition, biologic treatments targeting cytokines in OA have showed poor efficacy in clinical studies. This raises the question whether persistent inflammation has a central role in driving disease. The histone deacetylase Sirtuin 1 (SIR...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
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(pdf, 147.7KB)
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- Publisher copy:
- 10.1016/j.joca.2017.02.084
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- Publisher:
- Elsevier Publisher's website
- Publication date:
- 2017-04-18
- Acceptance date:
- 2017-01-09
- DOI:
- Pubs id:
-
pubs:724456
- URN:
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uri:bb3d7ab9-766c-4a0f-9d06-9238704cea29
- UUID:
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uuid:bb3d7ab9-766c-4a0f-9d06-9238704cea29
- Local pid:
- pubs:724456
- Copyright holder:
- Sacitharan et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Published by Elsevier Ltd. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.joca.2017.02.084
Conference item
Persistent global inflammation caused by the loss of SIRT1 protects against experimental osteoarthritis
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