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Thesis

The magnetoencephalographic signature of catechol-O-methyltransferase

Abstract:

Catechol-O-methyltransferase (COMT) metabolizes catechols, notably dopamine. The COMT Val158Met polymorphism influences its enzyme activity, and multiple neural correlates of this genotype on dopaminergic phenotypes have been reported, particularly with regards to working memory. COMT activity can also be regulated pharmacologically by COMT inhibitors. The ‘inverted-U’ relationship between dopamine signalling and cognitive performance predicts that the effects of COMT inhibition will differ ...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
St John's College
Department:
Medical Sciences Division - Psychiatry
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Funding agency for:
S.M. Farrell
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:bb375074-7912-4f8b-b123-975dff7d88e0
Local pid:
ora:6799

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