Collagenase penetrates human pancreatic islets following standard intraductal administration.

Journal article

BACKGROUND: : To optimize human islet isolation, it is important to improve our understanding of the collagenase digestion phase. Previous studies of collagenase action were mostly concerned with optimizing its composition, but the delivery and distribution of collagenase at the islet-exocrine interface is likely to be important for liberation of intact islets. The aim of this study was to characterize collagenase distribution in relation to islets in infused human pancreases. METHODS: : Hum...

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Authors: Cross, S; Hughes, S; Partridge, C; Clark, A; Gray, D

• Publication status: Published
• Journal: Transplantation
• Volume: 86
• Issue: 7
• Pages: 907-911
• Publication date: 2008-10-01
• DOI: 10.1097/tp.0b013e318186df87
• EISSN: 1534-6080
• ISSN: 0041-1337
• Language: English
• Keywords: Drug Administration Routes; Organ Preservation Solutions; Collagenases; Humans; Pancreas; Pancreas, Exocrine; Pancreatic Ducts; Islets of Langerhans