Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes

Traylor, M; Bevan, S; Rothwell, P; Sudlow, C; Dichgans, M; Markus, H; Lewis, C

Journal article

Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes

Abstract:: Genome-wide association studies (GWAS) have been successful in identifying common variants related to complex disorders. However, some disorders have proved resistant to this strategy with few associations confirmed, despite evidence from twin and family studies of a genetic component. Sophisticated strategies that account for phenotypic heterogeneity may be required to uncover these genetic contributions. Age at onset is an example of a potential source of this heterogeneity in ischaemic str...
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APA Style

Traylor, M., Bevan, S., Rothwell, P., Sudlow, C., Dichgans, M., Markus, H., & Lewis, C. (2013). Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes. Genetic Epidemiology, 37(5), 495–503.

MLA Style

Traylor, M., et al. “Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes.” Genetic Epidemiology, vol. 37, no. 5, 2013, pp. 495–503.

Chicago Style

Traylor, M, S Bevan, P Rothwell, C Sudlow, M Dichgans, H Markus, and C Lewis. 2013. “Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes.” Genetic Epidemiology 37 (5): 495–503.
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Publisher copy:: 10.1002/gepi.21729

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+ Traylor, M More by this author

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+ Bevan, S More by this author

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+ Rothwell, P More by this author

Institution:

University of Oxford

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MPLS

Department:

Engineering Science

Sub department:

Institute of Biomedical Engineering

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+ Sudlow, C More by this author

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+ Dichgans, M More by this author

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Bibliographic Details

Journal:: Genetic Epidemiology More from this journal
Volume:: 37
Issue:: 5
Pages:: 495-503
Publication date:: 2013-07-01
DOI:: 10.1002/gepi.21729
EISSN:: 1098-2272
ISSN:: 0741-0395

Item Description

Language:: English
Keywords:: Heterogeneity

Genome-wide association study

Age at onset

Ischaemic stroke
Pubs id:: pubs:410064
UUID:: uuid:bb2b51c3-383e-447c-8607-136610f49eea
Local pid:: pubs:410064
Source identifiers:: 410064
Deposit date:: 2013-11-17

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Licence:: Terms and Conditions of Use for Oxford University Research Archive

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Journal article

Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes

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