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Novel Adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man

Abstract:

Currently, no vaccine exists for hepatitis C virus (HCV), a major pathogen thought to infect 170 million people globally. Many studies suggest that host T cell responses are critical for spontaneous resolution of disease, and preclinical studies have indicated a requirement for T cells in protection against challenge. We aimed to elicit HCV-specific T cells with the potential for protection using a recombinant adenoviral vector strategy in a phase 1 study of healthy human volunteers. Two aden...

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Publication status:
Published
Peer review status:
Peer reviewed

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Default/Not Applicable
Role:
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Wellcome Trust More from this funder
NIAID NIH HHS More from this funder
Medical Research Council More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
4
Issue:
115
Pages:
115ra1
Publication date:
2012-01-04
Acceptance date:
2011-12-08
DOI:
ISSN:
1946-6234 and 1946-6242
Pubs id:
pubs:222385
URN:
uri:bb2adf4e-420e-4d2a-997e-016e90170f15
UUID:
bb2adf4e-420e-4d2a-997e-016e90170f15
Local pid:
pubs:222385
Paper number:
115

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