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Journal article

Inhibiting the proton pump: mechanisms, benefits, harms, and questions

Abstract:

Inhibition of the H+/K+-adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced pept...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12916-016-0724-1

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Oxford college:
Green Templeton; Green Templeton College
Role:
Author
ORCID:
0000-0003-1139-655X
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medicine Journal website
Volume:
14
Pages:
Article number 172
Publication date:
2016-11-09
Acceptance date:
2016-10-21
DOI:
EISSN:
1741-7015
Pubs id:
pubs:846619
URN:
uri:bb1ea1c6-e1f4-4eb3-aeb2-2a6a09d40d5b
UUID:
uuid:bb1ea1c6-e1f4-4eb3-aeb2-2a6a09d40d5b
Local pid:
pubs:846619

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