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Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.

Abstract:

After exposure to DNA-damaging agents that block the progress of the replication fork, monoubiquitination of proliferating cell nuclear antigen (PCNA) mediates the switch from replicative to translesion synthesis DNA polymerases. We show that in human cells, PCNA is monoubiquitinated in response to methyl methanesulfonate and mitomycin C, as well as UV light, albeit with different kinetics, but not in response to bleomycin or camptothecin. Cyclobutane pyrimidine dimers are responsible for mos...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0802727105

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
42
Pages:
16125-16130
Publication date:
2008-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:bb173f15-92a4-435e-b4c0-c8c577ccf508
Source identifiers:
365399
Local pid:
pubs:365399

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