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Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-γ-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.

Abstract:

Asthma and other allergic diseases are continuously increasing, causing considerable economic and sociologic burden to society. The hygiene hypothesis proposes that lack of microbial T helper (Th) 1-like stimulation during early childhood leads to increased Th2-driven allergic disorders later in life. Immunostimulatory cytosine-phosphate-guanosine (CpG)-oligodeoxynucleotide motifs are candidate molecules for immunotherapeutic studies, as they have been shown to shift the Th2 response toward t...

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Publisher copy:
10.1165/rcmb.2009-0355oc

Authors


Haapakoski, R More by this author
Karisola, P More by this author
Fyhrquist, N More by this author
Savinko, T More by this author
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Journal:
American journal of respiratory cell and molecular biology
Volume:
44
Issue:
5
Pages:
639-647
Publication date:
2011-05-05
DOI:
EISSN:
1535-4989
ISSN:
1044-1549
URN:
uuid:bb12509c-7424-4f6d-af73-73689e3c97ba
Source identifiers:
387513
Local pid:
pubs:387513

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