Journal article icon

Journal article

Vascular hyperpolarization to β-adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries.

Abstract:

BACKGROUND AND PURPOSE: β-Adrenoceptor stimulation causes pronounced vasodilatation associated with smooth muscle hyperpolarization. Although the hyperpolarization is known to reflect K(ATP) channel activation, it is not known to what extent it contributes to vasodilatation. EXPERIMENTAL APPROACH: Smooth muscle membrane potential and tension were measured simultaneously in small mesenteric arteries in a wire myograph. The spread of vasodilatation over distance was assessed in pressurized arte...

Expand abstract

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Br J Pharmacol
Volume:
164
Issue:
3
Pages:
913-921
Publication date:
2011-10-01
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Source identifiers:
112543
Language:
English
Keywords:
Pubs id:
pubs:112543
UUID:
uuid:bb0f6df1-54be-497d-bbf7-5ed2504357dc
Local pid:
pubs:112543
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP