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Vascular hyperpolarization to β-adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries.

Abstract:

BACKGROUND AND PURPOSE: β-Adrenoceptor stimulation causes pronounced vasodilatation associated with smooth muscle hyperpolarization. Although the hyperpolarization is known to reflect K(ATP) channel activation, it is not known to what extent it contributes to vasodilatation. EXPERIMENTAL APPROACH: Smooth muscle membrane potential and tension were measured simultaneously in small mesenteric arteries in a wire myograph. The spread of vasodilatation over distance was assessed in pressurized arte...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Yarova, PL More by this author
Jiménez-Altayó, F More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Journal:
Br J Pharmacol
Volume:
164
Issue:
3
Pages:
913-921
Publication date:
2011-10-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:bb0f6df1-54be-497d-bbf7-5ed2504357dc
Source identifiers:
112543
Local pid:
pubs:112543

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