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Cellular and humoral mechanisms of osteoclast formation in Ewing's sarcoma.

Abstract:

Cellular mechanisms that account for tumour osteolysis associated with Ewing's sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells (MNCs) that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor-kappaB (RANK) ligand (RANKL)-dependent and -independent mechanisms. In this study, our aim has been to determine whether tumour-associated macrophages (TAMs) isolated from Ewing's sarcoma are capable of different...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6603774

Authors


Adamopoulos, IE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Gibbons, CL More by this author
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Journal:
British journal of cancer
Volume:
96
Issue:
11
Pages:
1716-1722
Publication date:
2007-06-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:bb0d9cc3-bc7b-4d1b-b13d-c74ae48f7ca3
Source identifiers:
103873
Local pid:
pubs:103873

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