Cellular and humoral mechanisms of osteoclast formation in Ewing's sarcoma.

Journal article

Cellular mechanisms that account for tumour osteolysis associated with Ewing's sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells (MNCs) that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor-kappaB (RANK) ligand (RANKL)-dependent and -independent mechanisms. In this study, our aim has been to determine whether tumour-associated macrophages (TAMs) isolated from Ewing's sarcoma are capable of different...

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Authors: Lau, Y; Adamopoulos, I; Sabokbar, A; Giele, H; Gibbons, C

• Publication status: Published
• Journal: British journal of cancer
• Volume: 96
• Issue: 11
• Pages: 1716-1722
• Publication date: 2007-06-01
• DOI: 10.1038/sj.bjc.6603774
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Adolescent; Humans; Tumor Necrosis Factor-alpha; Cell Differentiation; Adult; Middle Aged; Aged; Female; Macrophages; Male; Osteoclasts; Sarcoma, Ewing; Osteoprotegerin; RANK Ligand; TNF-Related Apoptosis-Inducing Ligand; Bone Resorption; Bone Neoplasms; Bone and Bones; Tumor Cells, Cultured; Stromal Cells