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Journal article

Developmental diet regulates Drosophila lifespan via lipid autotoxins

Abstract:

Early-life nourishment exerts long-term influences upon adult physiology and disease risk. These lasting effects of diet are well established but the underlying mechanisms are only partially understood. Here we show that restricting dietary yeast during Drosophila development can, depending upon the subsequent adult environment, more than double median lifespan. Developmental diet acts via a long-term influence upon the adult production of toxic molecules, which we term autotoxins, that are s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-017-01740-9

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Role:
Author
ORCID:
0000-0002-4124-6950
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Role:
Author
ORCID:
0000-0002-8641-5818
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Role:
Author
ORCID:
0000-0003-4289-3815
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Role:
Author
ORCID:
0000-0003-1809-2305
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Article number:
1384
Publication date:
2017-11-09
Acceptance date:
2017-10-13
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
29123106
Source identifiers:
746013
Language:
English
Keywords:
Pubs id:
pubs:746013
UUID:
uuid:bafda1a7-c137-47af-9bd2-033f5975d2dc
Local pid:
pubs:746013
Deposit date:
2019-02-13

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