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Developmental diet regulates Drosophila lifespan via lipid autotoxins

Abstract:

Early-life nourishment exerts long-term influences upon adult physiology and disease risk. These lasting effects of diet are well established but the underlying mechanisms are only partially understood. Here we show that restricting dietary yeast during Drosophila development can, depending upon the subsequent adult environment, more than double median lifespan. Developmental diet acts via a long-term influence upon the adult production of toxic molecules, which we term autotoxins, that are s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-017-01740-9

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Role:
Author
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Role:
Author
ORCID:
0000-0002-4124-6950
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Role:
Author
ORCID:
0000-0002-8641-5818
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Role:
Author
ORCID:
0000-0003-4289-3815
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Role:
Author
ORCID:
0000-0003-1809-2305
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Grant:
FC001088
104566/Z/14/Z
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
Article: 1384
Publication date:
2017-11-09
Acceptance date:
2017-10-13
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:746013
URN:
uri:bafda1a7-c137-47af-9bd2-033f5975d2dc
UUID:
uuid:bafda1a7-c137-47af-9bd2-033f5975d2dc
Local pid:
pubs:746013

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