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Understanding the role of CFP1 at CpG islands

Abstract:

Vertebrate genomes are punctuated by CpG islands regions, which have an elevated frequency of CpG dinucleotides. CpG islands are associated with over 70% of mammalian promoters suggesting they may contribute to the regulation of transcription. However, despite being discovered over 30 years ago, the function of CpG islands is still not understood. Unlike the majority of the genome, CpG islands are resistant to DNA methylation. This provides a binding site for CFP1 which binds specifically ...

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Institution:
University of Oxford
Research group:
Professor Rob Klose
Oxford college:
Exeter College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
David Alexander Brown
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:baf2e91a-4417-407a-8938-bbef1f6c411f
Local pid:
ora:11748

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