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Thesis

Mathematical modelling of Centrosomin incorporation in Drosophila centrosomes

Abstract:

Centrosomin (Cnn) is an integral centrosomal protein in Drosophila with orthologues in several species, including humans. The human orthologue of Cnn is required for brain development with Cnn hypothesised to play a similar role in Drosophila. Control of Cnn incorporation into centrosomes is crucial for controlling asymmetric division in certain types of Drosophila stem cells. FRAP experiments on Cnn show that Cnn recovers in a pe- culiar fashion, which suggest that Cnn may be incorporated...

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Institution:
University of Oxford
Research group:
Centre for Mathematical Biology
Oxford college:
Linacre College
Department:
Mathematical,Physical & Life Sciences Division - Mathematical Institute

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Suruchi Bakshi
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:baefde65-bc38-4a11-bd92-e2e4cccad784
Local pid:
ora:8680

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