Modeling the effects of transforming growth factor-beta on extracellular matrix alignment in dermal wound repair.

Journal article

We present a novel mathematical model for collagen deposition and alignment during dermal wound healing, focusing on the regulatory effects of transforming growth factor-beta (TGFbeta.) Our work extends a previously developed model which considers the interactions between fibroblasts and an extracellular matrix composed of collagen and a fibrin based blood clot, by allowing fibroblasts to orient the collagen matrix, and produce and degrade the extracellular matrix, while the matrix directs th...

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Authors: Dallon, J; Sherratt, J; Maini, P

• Publication status: Published
• Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
• Volume: 9
• Issue: 4
• Pages: 278-286
• Publication date: 2001-01-01
• DOI: 10.1046/j.1524-475x.2001.00278.x
• EISSN: 1524-475X
• ISSN: 1067-1927
• Language: English
• Keywords: Collagen; Cell Movement; Models, Anatomic; Transforming Growth Factor beta; Extracellular Matrix; Humans; Sensitivity and Specificity; Models, Theoretical; Wounds and Injuries; Injury Severity Score; Epidermis; Wound Healing; Regeneration