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Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells.

Abstract:

Factors that aid survival of prostate cancer cells in the presence of the various categories of cytotoxic cytokines present in tumors in vivo are largely unknown. Osteoprotegerin (OPG) is a decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) that inhibits TRAIL-induced apoptosis. In relation to this activity, we hypothesized that the ability to produce OPG by prostate cancer cells would confer a survival advantage on these cells. In this study we have demonstrat...

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Publication status:
Published

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Authors


Croucher, PI More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
Journal:
Cancer research
Volume:
62
Issue:
6
Pages:
1619-1623
Publication date:
2002-03-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:bad81d89-0f6e-4fc7-849f-acfbfceb3a64
Source identifiers:
120594
Local pid:
pubs:120594

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