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Journal article

Spiroindolones, a potent compound class for the treatment of malaria.

Abstract:

Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-beta-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates at low nanomolar concentration. Spiroindolones rapidly inhibit protein synthesis in P. falciparum, an effect that is ablated in parasites bearing nonsynonymous mutations in the...

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Publication status:
Published

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Publisher copy:
10.1126/science.1193225

Authors


Rottmann, M More by this author
McNamara, C More by this author
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Journal:
Science (New York, N.Y.)
Volume:
329
Issue:
5996
Pages:
1175-1180
Publication date:
2010-09-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:bad6c805-671d-4af0-b255-646c180a32b1
Source identifiers:
71156
Local pid:
pubs:71156

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