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Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression.

Abstract:

OBJECTIVE: Although autoantibody production is a key feature of autoimmunity, it is not known whether variation in autoantibody production and clearance pathways is involved in disease susceptibility. The Fc Gamma Receptor IIa (FcGRIIa) molecule is involved in the clearance of autoantibodies and a functional single nucleotide polymorphism (SNP), rs1801274, which has been shown to alter autoantibody clearance, has been associated with a number of autoimmune diseases (AIDs) including systemic ...

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Authors


Hargreaves, C More by this author
Heward, JM More by this author
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Journal:
Clinical endocrinology
Volume:
73
Issue:
1
Pages:
119-125
Publication date:
2010-07-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:bad19ad1-ab57-4c81-9720-c21062693df0
Source identifiers:
176422
Local pid:
pubs:176422

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