Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study.

Journal article

Osteoporosis is a common disease with a strong genetic component, characterized by reduced bone mass and an increased risk of fracture. Bone mineral density (BMD) is a highly heritable trait and a key determinant of osteoporotic fracture risk, but the genes responsible are incompletely defined. Here, we identified quantitative trait loci (QTL) for regulation of BMD by a genome wide scan involving 3691 individuals from 715 families, who were selected because of reduced BMD values at the lumbar...

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Authors: Ralston, S; Galwey, N; MacKay, I; Albagha, O; Cardon, L

• Publication status: Published
• Journal: Human molecular genetics
• Volume: 14
• Issue: 7
• Pages: 943-951
• Publication date: 2005-04-01
• DOI: 10.1093/hmg/ddi088
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Female; Genome; Lumbar Vertebrae; Lod Score; Humans; Quantitative Trait Loci; Sex Factors; Genotype; Genome, Human; Femur Neck; Genetic Linkage; Sequence Analysis, DNA; Bone Density; Male; Osteoporosis