Opioid antagonists for smoking cessation

Journal article

Background: The reinforcing properties of nicotine may be mediated through release of various neurotransmitters both centrally and systemically. People who smoke report positive effects such as pleasure, arousal, and relaxation as well as relief of negative affect, tension, and anxiety. Opioid (narcotic) antagonists are of particular interest to investigators as potential agents to attenuate the rewarding effects of cigarette smoking. Objectives: To evaluate the efficacy of opioid antagonists...

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Authors: David, S; Lancaster, T; Stead, L; Evins, A; Cahill, K

• Journal: Cochrane Database of Systematic Reviews
• Issue: 4
• Publication date: 2009-01-01
• DOI: 10.1002/14651858.CD003086.pub2
• ISSN: 1469-493X
• Language: English
• Keywords: Smoking cessation [*methods]; Randomized controlled trials as topic; Buprenorphine [therapeutic use]; Smoking [*drug therapy]; Naltrexone [therapeutic use]; Humans; Narcotic antagonists [*therapeutic use]; Naloxone [therapeutic use]