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An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug.

Abstract:

A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) complex resulted in synergistic effects between the metallic centre and the steroidal ligand, creating...

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Publication status:
Published

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Publisher copy:
10.1039/c0dt00838a

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
Browning, MJ More by this author
Navarro-Ranninger, C More by this author
Quiroga, AG More by this author
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Journal:
Dalton transactions (Cambridge, England : 2003)
Volume:
39
Issue:
47
Pages:
11353-11364
Publication date:
2010-12-05
DOI:
EISSN:
1477-9234
ISSN:
1477-9226
URN:
uuid:baac95c0-13ff-44d5-a3c3-e4c64ffb149b
Source identifiers:
154800
Local pid:
pubs:154800

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