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Skewed maturation of memory HIV-specific CD8 T lymphocytes.

Abstract:

Understanding the lineage differentiation of memory T cells is a central question in immunology. We investigated this issue by analysing the expression of the chemokine receptor CCR7, which defines distinct subsets of naive and memory T lymphocytes with different homing and effector capacities and antiviral immune responses to HIV and cytomegalovirus. Ex vivo analysis of the expression of CD45RA and CCR7 antigens, together with in vitro analysis of the cell-division capacity of different memo...

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Publisher copy:
10.1038/35065118

Authors


Champagne, P More by this author
Knabenhans, C More by this author
Ellefsen, K More by this author
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Journal:
Nature
Volume:
410
Issue:
6824
Pages:
106-111
Publication date:
2001-03-01
DOI:
ISSN:
0028-0836
URN:
uuid:baa5a5b3-5b04-43c2-a41f-d362908727e8
Source identifiers:
176590
Local pid:
pubs:176590

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