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Persistence of specific bactericidal antibodies at 5 years of age after vaccination against serogroup B meningococcus in infancy and at 40 months.

Abstract:

BACKGROUND: The multicomponent serogroup B meningococcal (4CMenB) vaccine induces antibodies against indicator strains of serogroup B meningococcus under various schedules. We investigated the persistence of antibodies in 5-year-old children 18-20 months after their last dose (at about 3.5 years of age). METHODS: We assessed 5-year-old children who received the 4CMenB vaccine or a recombinant protein vaccine in a previous randomized trial. We also recruited 50 vaccine-naive 5-year-olds and ad...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1503/cmaj.141200

Authors


McQuaid, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Robinson, H More by this author
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Novartis Vaccines More from this funder
Publisher:
Canadian Medical Association Publisher's website
Journal:
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Journal website
Volume:
187
Issue:
7
Pages:
E215-E223
Publication date:
2015
DOI:
EISSN:
1488-2329
ISSN:
0820-3946
URN:
uuid:baa3ee04-60b4-4852-8ce9-e5d47ceb9b30
Source identifiers:
515003
Local pid:
pubs:515003

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