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The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine

Abstract:

BACKGROUND: Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk. METHODOLOGY/PRINCIPAL FINDINGS: MSMB ex...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0013363

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
5
Issue:
10
Pages:
e13363
Publication date:
2010-10-13
Acceptance date:
2010-09-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
107869

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