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Effect of CTCF and Cohesin on the dynamics of RNA polymerase II transcription and coupled pre-messenger RNA processing

Abstract:

The CCCTC-binding factor (CTCF) is a versatile, multifunctional zinc-finger protein involved in a broad spectrum of cellular functions. In mammalian cells, CTCF functions together with the Cohesin complex, an essential regulator of sister chromatid cohesion. Together, CTCF and Cohesin have been shown to regulate gene expression at a genome-wide level in mammalian cells. In the yeast Saccharomyces pombe, Cohesin has been implicated in transcription termination of convergently trans...

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Institution:
University of Oxford
Oxford college:
Lincoln College
Department:
Mathematical,Physical & Life Sciences Division
Role:
Author

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Funding agency for:
Olga Liska
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:ba9454b8-4498-42c8-bc4c-16dd971af164
Local pid:
ora:9190

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