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Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA).

Abstract:

β-Lactam antibiotics have long been a treatment of choice for bacterial infections since they bind irreversibly to Penicillin-Binding Proteins (PBPs), enzymes that are vital for cell wall biosynthesis. Many pathogens express drug-insensitive PBPs rendering β-lactams ineffective, revealing a need for new types of PBP inhibitors active against resistant strains. We have identified alkyl boronic acids that are active against pathogens including methicillin-resistant S. aureus (MRSA). The crystal...

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Publication status:
Published

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Publisher copy:
10.1021/cb2001846

Authors


Journal:
ACS chemical biology
Volume:
6
Issue:
9
Pages:
943-951
Publication date:
2011-09-01
DOI:
EISSN:
1554-8937
ISSN:
1554-8929
Source identifiers:
177343

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