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Journal article

Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression.

Abstract:

Precise spatiotemporal control of Gata1 expression is required in both early hematopoietic progenitors to determine erythroid/megakaryocyte versus granulocyte/monocyte lineage output and in the subsequent differentiation of erythroid cells and megakaryocytes. An enhancer element upstream of the mouse Gata1 IE (1st exon erythroid) promoter, mHS-3.5, can direct both erythroid and megakaryocytic expression. However, loss of this element ablates only megakaryocytes, implying that an additional el...

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Publication status:
Published

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Journal:
Blood
Volume:
115
Issue:
17
Pages:
3463-3471
Publication date:
2010-04-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:ba850390-b68f-4372-8db5-d591e4ff3274
Source identifiers:
48928
Local pid:
pubs:48928

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