Synthesis and bioassay of 4-substituted 2-oxoglutaric acids
- Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factor-inhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.
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- CHINESE CHEMICAL LETTERS
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