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Synthesis and bioassay of 4-substituted 2-oxoglutaric acids

Abstract:
Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factor-inhibiting hypoxia-inducible factor (FIH) was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglutaric acids have great influence on their inhibitor activity.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
CHINESE CHEMICAL LETTERS
Volume:
17
Issue:
2
Pages:
156-158
Publication date:
2006-02-05
ISSN:
1001-8417
URN:
uuid:ba778642-6720-45f8-b74e-1dbadb9c2346
Source identifiers:
39883
Local pid:
pubs:39883
Language:
English
Keywords:

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