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Journal article

Spindle-E acts antivirally against alphaviruses in mosquito cells

Abstract:

Mosquitoes transmit several human- and animal-pathogenic alphaviruses (Togaviridae family). In alphavirus-infected mosquito cells two different types of virus-specific small RNAs are produced as part of the RNA interference response: short-interfering (si)RNAs and PIWI-interacting (pi)RNAs. The siRNA pathway is generally thought to be the main antiviral pathway. Although an antiviral activity has been suggested for the piRNA pathway its role in host defences is not clear. Knock down of key pr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/v10020088

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Sreenu, VB More by this author
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Funding agency for:
Varjak, M
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Funding agency for:
Schnettler, E
Publisher:
MDPI Publisher's website
Journal:
Viruses Journal website
Volume:
10
Issue:
2
Pages:
Article: 88
Publication date:
2018-02-18
Acceptance date:
2018-02-15
DOI:
EISSN:
1999-4915
ISSN:
1999-4915
Pubs id:
pubs:828969
URN:
uri:ba6a238a-988e-4ca9-bae0-ff62cd8c1ef3
UUID:
uuid:ba6a238a-988e-4ca9-bae0-ff62cd8c1ef3
Local pid:
pubs:828969

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