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Journal article

HIV entry in macrophages is dependent on intact lipid rafts.

Abstract:

Macrophages are an important natural target cell for HIV-1, but previous studies of virus entry into these cells are limited, and the involvement of membrane cholesterol and lipid rafts is unknown. Cholesterol disruption of macrophage membranes using four pharmacological agents acting by different mechanisms: methyl-beta cyclodextrin, nystatin, filipin complex and Lovastatin, all significantly inhibited productive HIV entry and reverse transcription. The inhibitory effects of these drugs resu...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2008.12.031

Authors


Carter, GC More by this author
Bernstone, L More by this author
Sangani, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Virology
Volume:
386
Issue:
1
Pages:
192-202
Publication date:
2009-03-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:ba6355ed-855b-4391-b61a-ba2b5d84f569
Source identifiers:
10082
Local pid:
pubs:10082

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