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The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.

Abstract:

The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-ALL), including four cases that arose as adverse events in gene therapy trials. To investigate the cellular origin of LMO2-induced leukemia, we used cell fate mapping to study mice in which the Lmo2 gene was constitutively expressed in the thymus. Lmo2 induced self-renewal of committed T cells in the mice more than 8 months before the development of overt T-ALL. These self-renewing cells retained the capacity f...

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Publisher copy:
10.1126/science.1182378

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Journal:
Science (New York, N.Y.)
Volume:
327
Issue:
5967
Pages:
879-883
Publication date:
2010-02-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:ba5ea009-7a44-4a64-a91a-30a83a705163
Source identifiers:
266420
Local pid:
pubs:266420

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