The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.

Journal article

The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-ALL), including four cases that arose as adverse events in gene therapy trials. To investigate the cellular origin of LMO2-induced leukemia, we used cell fate mapping to study mice in which the Lmo2 gene was constitutively expressed in the thymus. Lmo2 induced self-renewal of committed T cells in the mice more than 8 months before the development of overt T-ALL. These self-renewing cells retained the capacity f...

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Authors: McCormack, M; Young, L; Vasudevan, S; de Graaf, C; Codrington, R

• Journal: Science (New York, N.Y.)
• Volume: 327
• Issue: 5967
• Pages: 879-883
• Publication date: 2010-02-01
• DOI: 10.1126/science.1182378
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Humans; T-Lymphocyte Subsets; Precursor Cells, T-Lymphoid; Animals; Transcription, Genetic; DNA-Binding Proteins; Homeodomain Proteins; LIM Domain Proteins; Preleukemia; Oligonucleotide Array Sequence Analysis; Metalloproteins; Proto-Oncogene Proteins; Adaptor Proteins, Signal Transducing; Thymus Gland; Gene Expression Profiling; Mice; Oncogenes; T-Lymphocytes; Mice, Transgenic; Cell Transformation, Neoplastic; Down-Regulation; Up-Regulation; Cell Differentiation; Gene Expression Regulation, Leukemic; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Transcription Factors