Antisera recognising HLA-A, -B and DRW antigens raised in rhesus monkeys.

Journal article

Rhesus monkeys were immunized with partially purified HLA-A, -B, -C and DR antigens. The resulting sera were shown to have activity against species-specific determinants on both HLA-A, -B, -C chains and beta 2 microglobulin by the use of somatic cell hybrids. When this was removed by absorption, the sera showed activity against three of the four HLA-A and -B antigens in the immunogen when tested on a panel of peripheral blood lymphocytes and T cells. Antibodies recognizing HLA-DR antigens wer...

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Authors: Barnstable, C; Snary, D; Crumpton, M; Balner, H; Bodmer, W

• Publication status: Published
• Journal: Tissue antigens
• Volume: 15
• Issue: 5
• Pages: 407-418
• Publication date: 1980-05-01
• DOI: 10.1111/j.1399-0039.1980.tb00203.x
• EISSN: 1399-0039
• ISSN: 0001-2815
• Language: English
• Keywords: Immune Sera; Species Specificity; Epitopes; Glycoproteins; beta 2-Microglobulin; Cells, Cultured; T-Lymphocytes; HLA Antigens; Humans; B-Lymphocytes; Antigen-Antibody Reactions; Cytotoxicity Tests, Immunologic; Animals; Macaca mulatta; Macaca; Histocompatibility Antigens Class II